Table 2. Proteinase 3 (Pr3) peptides identified by epitope mapping.
Donor ID | Pr3 | Peptide sequence | HLA restriction | AA no. | HLA-A | HLA-B | HLA-Cw | HLA-DRB | HLA-DQB | Reference and HLA-restriction |
---|---|---|---|---|---|---|---|---|---|---|
2 | No. 9/10 | EAQPHSRPYMASLQMRGNP | Class I | 33–51 | 0201/01 | 08/44 | 05/07 | 0301/0401 | 0201/0301 | |
3 | No. 16 | IHPSFVLTAPHCLRD | Not identified | 61–75 | 0201/26 | 27/39 | 07/12 | 1501/1601 | 0502/0602 | |
9 | No. 15 | GGTLIHPSFVLTAPH | HLA-DR | 57–71 | 03/11 | 07/56 | 01/07 | 0101/0701 | 02/0501 | |
10 | No. 25 | QQHFSVAQVFLNNYD | Not identified | 97–111 | 0301/30 | 15/42 | 03/17 | 0401/0901 | 02/03 | |
No. 29 | ENKLNDILLIQLSSP | Not identified | 113–127 | |||||||
No. 57 | ATRLFPDFFTRVALY | Not identified | 225–239 | Lacey et al.45 HLA-A*0201 | ||||||
NO. 61 | DWIRSTLRRVEAKGR | Not identified | 241–255 | Piesche et al.46 HLA-DR |
Abbreviation: AA, amino acids, HLA, human leukocyte antigen.