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. Author manuscript; available in PMC: 2013 Dec 18.
Published in final edited form as: Angiogenesis. 2012 Sep 29;16(1):10.1007/s10456-012-9308-7. doi: 10.1007/s10456-012-9308-7

Fig. 3.

Fig. 3

Effects of SP2012 and SP5031 on vascular endothelial growth factor receptor 2 (VEGFR2) and focal adhesion kinase (FAK). a SP2012 and SP5031 block induction of VEGFR2 phosphorylation and in combination degrade total VEGFR2 in VEGF-stimulated HUVECs. b SP2012 and SP5031 block phosphorylation of focal adhesion kinase (FAK) additively and induce FAK degradation. c Downstream from VEGFR2, SP2012 and SP5031 block phosphor-ylation of pPLCγ. The peptides together show additivity in the presence of VEGF. d SP2012 and SP5031 block phosphorylation of VEGFR2 in LECs. This effect is additive at low and high doses of SP2012. e SP2012 and SP5031 block phosphorylation of FAK in LECs at low and high doses of SP2012