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Schematic of signaling pathways blocked by SP2012 collagen IV peptide and SP5031 somatotropin peptide in combination. Both SP2012 and SP5031 modulate VEGFR2 signaling through inhibition of phosphorylation and protein turnover. FAK may be blocked directly by binding β1 integrins and through inhibition of VEGFR2 signaling. Both peptides additively block induction of PLCγ. SP2012 induces pAkt by activation of Flt3, but is compensated by an Akt inhibitor such as SP5031
