Table 2.
Antidepressants administered to patients in perioperative period (Total n = 530,416)
| Antidepressant | No SSRI n=457876 | SSRI n=72540 | p |
|---|---|---|---|
| N (%) | N (%) | ||
| SSRI Antidepressants | NA | 72540 (13.7%) | NA |
| Olanzapine/fluoxetine (Symbax) | NA | 18 (0.02%) | NA |
| Citalopram (Celexa) | NA | 10334 (14.3%) | NA |
| Escilatopram (Lexapro) | NA | 18380 (25.3%) | NA |
| Fluoxetine (Prozac) | NA | 12885 (17.8%) | NA |
| Paroxetine (Paxil) | NA | 11845 (16.3%) | NA |
| Sertraline (Zoloft) | NA | 19200 (26.5%) | NA |
| Fluvoxamine (Luvox) | NA | 193 (0.3%) | NA |
| Timing of SSRI | NA | NA | |
| SSRI administered prior to surgery | NA | 68095 (93.9%) | NA |
| SSRI administered after surgery only | NA | 4445 (6.1%) | NA |
| Any-non SSRI Antidepressants | 45004 (9.8%) | 9956 (13.7%) | <0.0001 |
| Serotonin and norepinephrine reuptake inhibitors (SNRI) | 23395 (5.1%) | 1315 (1.8%) | <0.0001 |
| Tricyclic antidepressants | 10737 (2.3%) | 3001 (4.1%) | <0.0001 |
| Monoamine Oxidase Inhibitors | 54 (0.01%) | 1 (0%) | 0.0052 |
| Other medications used in depression (e.g. trazodone) | 15623 (3.3%) | 6109 (8.4%) | <0.0001 |