Figure 6. Simulations reflecting gene KO qualitatively reproduce expected changes in disease outcome.

(A and B) Parasite burden after in silico knock out of T cells (A) or IFNγ (B), compared to the results from the baseline model (baseline) and in vivo ([58]; WT). (C) In silico knock out of IL-10 compared with [58] and data adapted from [61]). In all the panels, means and standard deviation are reported. Standard deviation is indicated by error bars or shaded areas.