Table 3.

Differential Diagnosis of thrombocytopenia in Chronic Lymphocytic Leukemia.

Chronic: Drug Induced: Previous treatment with purine analogs, alkylating agents and monoclonal antibodies such as rituximab and alemtuzumab Autoimmunity Bone marrow infiltration by leukemic cells Splenomegaly Coexisting chronic infections such as hepatitis C, HIV and Helicobacter pylori.

Acute: Acute bacterial, viral and fungal infections; sepsis Recently used drugs: prescribed and over the counter medications.