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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Neuropharmacology. 2013 Oct 28;77:10.1016/j.neuropharm.2013.10.010. doi: 10.1016/j.neuropharm.2013.10.010

Figure 1.

Figure 1

Effects of YQA14 on cocaine-enhanced BSR in rats. A: A representative rate-frequency function curve for BSR, illustrating BSR stimulation threshold (θ0), M50 and Ymax; B: Representative rate-frequency function curves for BSR, illustrating that cocaine (2 mg/kg, i.p.) shifted the rate-frequency function curve to the left, lowering the BSR threshold θ 0 value (i.e., enhancing BSR), without a change in the Ymax level. C: Systemic administration of YQA14 dose-dependently decreased cocaine-enhanced BSR. D: Systemic administration of YQA14 alone had no effect on basal BSR. **p<0.01 compared to vehicle control group.