Effects of YQA14 on cocaine-enhanced BSR in rats. A: A representative rate-frequency function curve for BSR, illustrating BSR stimulation threshold (θ0), M50 and Ymax; B: Representative rate-frequency function curves for BSR, illustrating that cocaine (2 mg/kg, i.p.) shifted the rate-frequency function curve to the left, lowering the BSR threshold θ 0 value (i.e., enhancing BSR), without a change in the Ymax level. C: Systemic administration of YQA14 dose-dependently decreased cocaine-enhanced BSR. D: Systemic administration of YQA14 alone had no effect on basal BSR. **p<0.01 compared to vehicle control group.