Table 1.

Targeting strategies for tumor-associated macrophages in mouse models.

Target or drug	Mechanism of action
CCL2-CCR2 axis	Prevents monocyte recruitment
CSF1-CSF1R axis	Inhibits/reprograms TAMs
CXCL12-CXCR4 axis	Prevents recruitment of macrophages
DNA repair mechanisms (trabectedin)	Targets TAMs
Clodronate and zoledronic acid	Induces macrophage apoptosis
Anti-CpG and IL-10 Ab	Prevents antitumor to protumor macrophage polarization
CD40 agonist	Restores tumor immunity
Sibilin	Suppresses NF-κB and STAT3 phosphorylation, blocks angiogenesis

Ab: Antibody; CSF1R: CSF1 receptor; TAM: Tumor-associated macrophage.