Table 1.
Symbol | Definition | |
---|---|---|
Design parameters | α t | Target Type I error rate |
Pt | Target power | |
θ * | ‘Scientifically important’ value of θ | |
Variance value used for planning | ||
n 0 | Planned sample size for αt, Pt, θ*, | |
Sample size allocation | π | Proportion of n0 used in internal pilot |
n1 = πn0 | Internal pilot sample size | |
n 1 +,min | Minimum size of final sample | |
n +,max | Maximum size of final sample | |
Unknown parameters | σ 2 | True variance |
Ratio of true to initial variance value | ||
θ | True value of secondary parameter |