Table 1.
Clinicopathologic Characteristics of Pancreatic Ductal Adenocarcinoma Tissue Microarray and Correlation With HOXB7 Expression
| Characteristic | Full Cohort (n = 145) | Low HOXB7 (n = 90) | High HOXB7 (n = 55 ) | P | |||
|---|---|---|---|---|---|---|---|
| No. of Patients | % | No. of Patients | % | No. of Patients | % | ||
| Age, y | |||||||
| ≤60 | 49 | 33.7 | 35 | 38.9 | 14 | 25.5 | .10 |
| >60 | 96 | 66.3 | 55 | 61.1 | 41 | 74.5 | |
| Sex | |||||||
| Female | 70 | 48.3 | 45 | 50.0 | 25 | 45.5 | .59 |
| Male | 75 | 51.7 | 45 | 50.0 | 30 | 54.5 | |
| Greatest tumor dimension | |||||||
| <3 cm | 86 | 59.3 | 51 | 56.7 | 35 | 63.6 | .33 |
| ≥3 cm | 59 | 40.7 | 39 | 43.3 | 20 | 36.4 | |
| Histologic grade | |||||||
| Well + moderate | 83 | 57.2 | 54 | 60.0 | 29 | 52.7 | .39 |
| Poor | 62 | 42.8 | 36 | 40.0 | 26 | 47.3 | |
| pT-stage | |||||||
| pT1 | 26 | 17.9 | 18 | 20.0 | 8 | 14.5 | .41 |
| pT2 + pT3 | 119 | 82.1 | 72 | 80.0 | 47 | 85.5 | |
| N-stage (categorized) | |||||||
| N0 | 69 | 47.6 | 49 | 54.4 | 20 | 36.4 | .034 |
| N1 | 76 | 52.4 | 41 | 45.6 | 35 | 63.6 | |
| AJCC stage | |||||||
| Stage I | 40 | 27.6 | 30 | 33.3 | 10 | 22.2 | .048 |
| Stage II | 105 | 72.4 | 60 | 66.6 | 45 | 81.8 | |
| Margin status | |||||||
| Negative (R0) | 126 | 86.9 | 78 | 87.7 | 48 | 87.3 | .70 |
| Positive (R1) | 19 | 13.1 | 12 | 13.3 | 7 | 12.7 | |
Abbreviation: AJCC, American Joint Commission on Cancer.
P value from 2-sided chi-square test evaluating low versus high HOXB7 for each characteristic.