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. 2013 Dec 12;8:4733–4743. doi: 10.2147/IJN.S50113

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© 2013 Burgess et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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(A and B) NanoDisk–amphotericin B (ND-AMB)^72C is an effective treatment for disseminated Candida albicans infection in immune-competent mice. (A) Kaplan–Meier plots of select groups (n=6) infected on day 0 and treated on days indicated (shaded circles). Treated mice received either ND-AMB^72C at 3 mg/kg/day (open circles), liposomal AMB (L-AMB) at 3 mg/kg/day (open squares), deoxycholate (DOC) at 1 mg/kg/day (open triangles), or isotonic dextrose as control (crosses). (B) Survival for all groups is summarized on day 6 for treatment groups ND-AMB^72C (closed bars), L-AMB (dark shading), DOC-AMB (light shading), or isotonic dextrose (open bars).