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. 2013 Dec 18;8(12):e82200. doi: 10.1371/journal.pone.0082200

Table 1. Top upregulated genes in high altitude acclimatized ovine fetal carotid arteries compared to normal control.

Symbol Entrez Gene Name Fold Change FH Mean FH SD FN Mean FN SD p-value
SLC16A3 Solute carrier family 16, member 3 (monocarboxylic acid transporter 4) 6.866 0.38 0.28 0.06 0.03 1.77E-02
TNC Tenascin C 5.704 4.72 3.49 0.83 0.38 2.47E-02
IGFBP3 Insulin-like growth factor binding protein 3 5.288 1.20 0.12 0.23 0.13 3.04E-02
TP53I11 Tumor protein p53 inducible protein 11 5.133 0.13 0.08 0.03 0.02 4.46E-02
IGF2R Insulin-like growth factor 2 receptor 4.906 0.59 0.41 0.12 0.04 2.99E-02
ATF3 Activating transcription factor 3 4.384 0.43 0.14 0.10 0.05 1.82E-02
SERPINH1 Serpin peptidase inhibitor, clade H (HSP47; collagen binding protein 1) 4.246 12.89 5.76 3.03 0.92 1.13E-02
PIM2 Pim-2 oncogene 3.489 0.07 0.01 0.02 0.01 3.40E-03
DCAF8 DDB1 and CUL4 associated factor 8 3.374 0.45 0.22 0.13 0.06 3.13E-02
TGFB3 Transforming growth factor, beta 3 2.919 1.43 0.50 0.49 0.26 4.56E-02
MYOT Myotilin 2.789 5.77 1.12 2.07 0.46 3.98E-03
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 2.613 0.23 0.05 0.09 0.03 1.38E-02
CRELD2 Cysteine-rich with EGF-like domains 2 2.597 0.43 0.16 0.17 0.02 4.07E-02
BCL2 B-cell CLL/lymphoma 2 2.549 0.85 0.24 0.33 0.16 4.83E-02
GNL1 Guanine nucleotide binding protein-like 1 2.52 0.35 0.10 0.14 0.06 4.20E-02
HR Hairless homolog (mouse) 2.499 0.17 0.02 0.07 0.02 9.53E-03
SNRNP70 Small nuclear ribonucleoprotein 70 kDa (U1) 2.485 1.12 0.46 0.45 0.10 3.78E-02
ATF6B Activating transcription factor 6 beta 2.386 0.29 0.10 0.12 0.04 3.48E-02
SURF6 Surfeit 6 2.351 0.21 0.06 0.09 0.04 4.88E-02
KDM4A Lysine (K)-specific demethylase 4A 2.327 0.42 0.11 0.18 0.04 1.17E-02
ACTN1 Actinin, alpha 1 2.326 23.45 2.57 10.08 1.35 1.24E-03
DYNC1H1 Dynein, cytoplasmic 1, heavy chain 1 2.307 3.16 0.49 1.37 0.53 4.59E-02
MED16 Mediator complex subunit 16 2.264 0.14 0.05 0.06 0.02 4.97E-02
ADIPOR1 Adiponectin receptor 1 2.247 0.39 0.08 0.17 0.05 2.31E-02
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 2.247 1.24 0.47 0.55 0.12 4.20E-02
MTMR2 Myotubularin related protein 2 2.231 0.22 0.08 0.10 0.03 4.78E-02
MTCH1 Mitochondrial carrier 1 2.224 5.12 1.75 2.30 0.35 3.63E-02
CDV3 CDV3 homolog (mouse) 2.206 0.46 0.15 0.21 0.07 4.51E-02
KHSRP KH-type splicing regulatory protein 2.153 0.27 0.07 0.13 0.02 1.34E-02
RBM42 RNA binding motif protein 42 2.153 1.91 0.50 0.89 0.30 3.58E-02
ATG4B ATG4 autophagy related 4 homolog B (S. cerevisiae) 2.119 1.46 0.46 0.69 0.10 3.55E-02
WASF2 WAS protein family, member 2 2.054 0.40 0.09 0.19 0.05 1.88E-02
COL18A1 Collagen, type XVIII, alpha 1 2.05 6.00 0.60 2.93 0.54 1.45E-02
PLXNB1 Plexin B1 2.047 0.56 0.10 0.27 0.09 4.24E-02
COX7B Cytochrome c oxidase subunit VIIb 2.045 0.64 0.15 0.31 0.09 3.01E-02
ANXA11 Annexin A11 2.026 0.93 0.21 0.46 0.16 4.46E-02
FADS2 Fatty acid desaturase 2 2.023 0.59 0.20 0.29 0.06 4.68E-02
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.019 5.00 0.52 2.48 0.52 1.41E-02