Table 2. Significantly different OTUs between T0 (before treatment) and T1 (first radiation therapy), between T0 and T2 (fifth radiation therapy), and between T0 and T3 (follow-up) samples (data only represent OTUs with > 0.1% abundance).

Sample	Taxon name	Abundance in T0 (%)	Tested stage (%)	Difference (%)	p-value
T0 vs. T1	Ruminococcus sp. CO28	0 ± 0	0.4 ± 0.4	0.4	0.001
	Roseburia sp. DJF VR77	0 ± 0	0.3 ± 0.3	0.3	0.001
	Ruminococcus sp. CO41	0 ± 0	0.2 ± 0.2	0.2	0.001
	Lachnospira pectinoschiza	0 ± 0	0.1 ± 0.1	0.1	0.001
	Weissella confuse	0.3 ± 0.2	0 ± 0	0.3	0.001
	Enterobacter sp. mcp11b	0.2 ± 0.2	0 ± 0	0.2	0.001
	Klebsiella pneumonia	0.1 ± 0.1	0 ± 0	0.1	0.001
	Adlercreutzia equolifaciens	0.1 ± 0.1	0 ± 0	0.1	0.001
T0 vs. T2	Butyrate-producing bacterium SS2/1	1.2 ± 0.4	4.1 ± 1.3	2.9	0.009
	Ruminococcus callidus	1.0 ± 0.5	0 ± 0	1.0	0.03
	Dialister sp. E2 20	1.0 ± 0.4	0 ± 0	1.0	0.013
	Human intestinal firmicute CB47	0.9 ± 0.3	4.4 ± 1.8	3.5	0.025
	Eubacterium eligens	0.8 ± 0.4	0.1 ± 0.1	0.7	0.032
	Eubacterium hallii	0.1 ± 0.1	0 ± 0	0.1	0.041
	Actinomyces odontolyticus	0.1 ± 0.1	0 ± 0	0.1	0.046
	Lactobacillus murinus	0.1 ± 0.1	0 ± 0	0.1	0.039
	Clostridiales bacterium DJF CP67	0 ± 0	0.2 ± 0.1	0.2	0.009
T0 vs. T3	Prevotella stercorea	0.3 ± 0.3	0 ± 0	0.3	0.001
	Clostridium sp. BG-C36	0.1 ± 0.1	0 ± 0	0.1	0.001
	Ruminococcus sp. DJF VR52	0 ± 0	0.6 ± 0.3	0.6	0.001
	Prevotella copri	0 ± 0	0.3 ± 0.3	0.3	0.001
	Ruminococcus sp. CO28	0 ± 0	0.3 ± 0.2	0.3	0.001
	Butyrate-producing bacterium T1-815	0 ± 0	0.2 ± 0.1	0.2	0.001
	Roseburia inulinivorans	0 ± 0	0.2 ± 0.1	0.2	0.001
	Bacteroides sp. CCUG 39913	0 ± 0	0.2 ± 0.2	0.2	0.001
	Swine fecal bacterium FPC110	0 ± 0	0.2 ± 0.2	0.2	0.001
	Faecalibacterium sp. DJF VR20	0 ± 0	0.2 ± 0.2	0.2	0.001
	Clostridium methylpentosum	0 ± 0	0.1 ± 0.1	0.1	0.001
	Oscillospira sp. BA04013493	0 ± 0	0.1 ± 0.1	0.1	0.001
	Candidatus Bacilloplasma	0 ± 0	0.1 ± 0.1	0.1	0.001
	Clostridiales bacterium A2-162	0 ± 0	0.1 ± 0.1	0.1	0.001
	Coriobacterium sp. CCUG 33918	0 ± 0	0.1 ± 0.1	0.1	0.001
	Amphibacillus sp. YIM-kkny6	0 ± 0	0.1 ± 0.1	0.1	0.001
	Lachnospiraceae bacterium DJF RP14	0 ± 0	0.1 ± 0.1	0.1	0.001
	Clostridium leptum	0 ± 0	0.1 ± 0.1	0.1	0.001
	Ruminococcus sp. CS1	0 ± 0	0.1 ± 0.1	0.1	0.001