Table 1. Biochemistry, liver function tests and haematology in pigs with ischaemic acute liver failure.
| Group 1 (Cell-bead BAL) average time after ischaemia = 2.55 h | Group 2 (Control empty bead BAL) average time after ischaemia = 2.33 h | ||||||||||||||
| TEST | Pigs: | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | normal range |
| ALBUMIN-S | g/L | 10 | 10 | 10 | 11 | 9 | 8 | 10 | 11 | 10 | 9 | 9 | 9 | 10 | 37–52 |
| ALK. PHOSPHATASE | µ/L 37′C | 137 | 129 | 115 | 224 | 97 | 124 | 155 | 164 | 123 | 103 | 161 | 153 | 63 | 40–120 |
| ALT (SGPT) | µ/L 37′C | 30 | 28 | 40 | 45 | 43 | 29 | 50 | 34 | 34 | 41 | 55 | 30 | 15 | 10–32 |
| AMMONIA PLASMA | µmol/L | 532 | 632 | 424 | 267 | 425 | 276 | 395 | 559 | 430 | 271 | 643 | 299 | 293 | 11.0–32.0 |
| ANION GAP | mmol/l | 19 | 23 | 17 | 15 | 18 | 16 | 19 | 16 | 22 | 15 | 21 | 17 | 12 | 5–15 |
| AST (SGOT) | µ/L 37′C | 77 | 117 | 96 | 172 | 513 | 129 | 65 | 56 | 55 | 42 | 405 | 130 | 14 | 10–32 |
| BILI CONJ.-S | µmol/L | 2 | 3 | 2 | 2 | 3 | 2 | 2 | 3 | 2 | 3 | 2 | 2 | 2 | 0–8 |
| BILI UNCONJ.-S | µmol/L | 7 | 7 | 7 | 6 | 8 | 5 | 5 | 4 | 8 | 6 | 8 | 7 | 5 | 2–14 |
| BILIRUBIN TOTAL-S | µmol/L | 9 | 10 | 9 | 8 | 11 | 7 | 7 | 7 | 10 | 9 | 10 | 9 | 7 | 2–20 |
| CALCIUM-S | mmol/L | 2.04 | 2.05 | 2.03 | 2.34 | 2.45 | 2.3 | 2.11 | 2.2 | 1.46 | 2.10–2.60 | ||||
| CO2-S | mmol/L | 20.6 | 12.9 | 16.4 | 21.1 | 15.4 | 16.8 | 19.4 | 24.6 | 18.2 | 16.3 | 11.9 | 18.9 | 12.6 | 22.0–30.0 |
| CREATININE-S | umol/L | 111 | 111 | 82 | 86 | 95 | 80 | 73 | 91 | 136 | 76 | 115 | 118 | 64 | 39–91 |
| FIBRINOGEN | g/L | 0.5 | 0.4 | 0.8 | 0.5 | 0.8 | 0.7 | 0.5 | 0.3 | 0.5 | 0.7 | 0.8 | 0.9 | 0.6 | 2.2–5.0 |
| GAMMA GT-S | µ/L 37′C | 33 | 34 | 35 | 37 | 25 | 27 | 36 | 25 | 37 | 19 | 47 | 26 | 16 | 5–40 |
| GLUCOSE | mmol/L | 6.2 | 3.9 | 2 | 4.9 | 2 | 5.4 | 7.4 | 8.4 | 19.9 | 7.2 | ||||
| HAEMATOCRIT | l/L | 0.39 | 0.34 | 0.4 | 0.36 | 0.32 | 0.29 | 0.4 | 0.35 | 0.38 | 0.39 | 0.25 | 0.31 | 0.21 | 0.35–0.45 |
| HAEMOGLOBIN | g/dL | 12.7 | 10.9 | 13.2 | 11.8 | 10.5 | 9.2 | 13.4 | 11.6 | 12 | 12.9 | 7.9 | 10.6 | 6.7 | 11.5–15.5 |
| INR | 2.8 | 2 | 3.4 | 2.6 | 2.6 | 3.8 | 2 | 3.2 | 4.2 | 2.4 | 1.5 | 3 | 3.9 | 0.9–1.3 | |
| LACTATE PLASMA | mmol/L | 5.9 | 10.1 | 4.8 | 4.5 | 9.6 | 3.3 | 3 | 5.8 | 8.5 | 4.9 | 11.1 | 5.2 | 4.2 | |
| PLATELET COUNT | x 10∧9/l | 154 | 192 | 271 | 335 | 237 | 178 | 224 | 236 | 323 | 238 | 211 | 260 | 190 | 140–420 |
| PROTHROMBIN TIME | sec | 26.6 | 19.5 | 32.1 | 25.1 | 24.6 | 35.9 | 19.4 | 30.2 | 39.9 | 22.5 | 14.9 | 28.2 | 36.9 | 9.8 |
| SODIUM-S | mmol/L | 139 | 142 | 139 | 142 | 144 | 142 | 140 | 145 | 141 | 136 | 146 | 140 | 147 | 136–144 |
| TOTAL PROTEIN-S | g/L | 40 | 41 | 41 | 45 | 35 | 29 | 42 | 45 | 41 | 40 | 40 | 41 | 26 | 60–82 |
| UREA-S | mmol/L | 3.1 | 4 | 3.3 | 1.1 | 3.3 | 1.5 | 1.6 | 2.4 | 2.1 | 1.8 | 3.2 | 3 | 1.5 | 2.5–6.7 |
| WHITE CELL COUNT | x 10∧9/l | 26.6 | 13.9 | 13.3 | 20.7 | 22.5 | 10.3 | 17.8 | 18.6 | 17.5 | 12.1 | 17.3 | 13.9 | 9 | 4.0–11.0 |
Group 1 = animals to be treated with a Cell-Bead BAL (bold) and Group 2 = animals to be treated with a control empty bead non functional BAL (plain text). Data are from blood samples taken at the start of the BAL addition, representing baseline acute liver failure (normal range in italics).