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. 2013 Dec 18;8(12):e82677. doi: 10.1371/journal.pone.0082677

Figure 5. Changes in the number of TUNEL-positive myocytes in the experimental pigs at 24 h after ROSC.

Figure 5

(A) Percentages of cardiomyocytes with TUNEL-positive nuclei. Cell apoptosis is another effect of I/R injury and can serve as a measure of the extent of I/R injury. In this study, we found that EE treatment alleviated myocyte apoptosis during I/R, evidenced by reducing amounts of TUNEL-positive cardiomyocytes, compared with SA group (P<0.01) and EP group (P<0.05). The value represent mean ± SD. SA  =  saline, EP =  epinephrine, EE  =  epinephrine combined with esmolol. *p<0.05, **p<0.01 vs.SA, #P<0.05 vs. EP (repeated-measures ANOVA). (B) Representative TUNEL-stained sections. The brown nuclei indicate TUNEL-positive nuclei.