Table 1. Immunohistochemical analysis of Slug expression in esophageal tissues and their correlation with clinicopathological parameters.
| Tissue type | Total cases (N) |
Cytoplasmic Positivity
|
p-value* | O.R. | (95% CI) |
Nuclear Positivity
|
p-value** | O.R. | (95% CI) | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n | (%) | n | (%) | ||||||||
| Normal | 47 | 9 | (19) | -- | -- | -- | -- | -- | -- | -- | -- |
| Dysplasia | 61 | 24 | (39.3) | 0.001a | 4.7 | (1.8-10.9) | 11 | (18) | <0.001b | 1.36 | (1.16-1.58) |
| Mild | 47 | 12 | (25.5) | <0.001c | 4 | (8.5) | 0.001d | ||||
| Moderate | 8 | 6 | (75) | 3 | (37.5) | ||||||
| Severe | 6 | 6 | (100) | <0.001e | 4.20 | (2.10-8.37) | 4 | (66.7) | 0.008f | 2.90 | (1.30-6.46) |
| ESCC | 91 | 64 | (70.3) | <0.001g | 10 | (4.5-23.5) | 27 | (29.7) | <0.001h | 1.42 | (1.24-1.62) |
| Gender | |||||||||||
| Male | 60 | 40 | (66.7) | 15 | (25) | ||||||
| Female | 31 | 24 | (77.4) | 0.2 | 1.7 | (0.63-4.6) | 12 | (38.7) | 0.133 | 1.9 | (0.75-4.8) |
| Age (years) | |||||||||||
| < 54 | 42 | 32 | (76.2) | 13 | (31) | ||||||
| > 54 | 49 | 32 | (65.3) | 0.18 | 0.59 | (0.23-1.5) | 14 | (28.6) | 0.49 | 0.9 | (0.36-2.2) |
| Tumor Stage | |||||||||||
| (T1+T2) | 10 | 7 | (70) | 1 | (10) | ||||||
| (T3+T4) | 81 | 57 | (70.3) | 0.61 | 1.0 | (0.24-4.2) | 26 | (32.1) | 0.13 | 4.2 | (0.5-35.3) |
| Nodal status | |||||||||||
| N0 | 27 | 19 | (70.3) | 6 | (22.2) | ||||||
| N1-4 | 64 | 45 | (70.3) | 0.60 | 1.0 | (0.37-2.7) | 21 | (30.3) | 0.226 | 1.7 | (0.6-4.8) |
| Histological differentiation | |||||||||||
| WDSCC | 28 | 22 | (78.6) | 9 | (32.1) | ||||||
| MDSCC+PDSCC | 63 | 48 | (66.7) | 0.18 | 0.5 | (0.2-1.5) | 18 | (28.6) | 0.45 | 0.86 | (0.3-2.2) |
| Tobacco habits | |||||||||||
| Non-smoker | 38 | 27 | (71) | 0.54 | -- | -- | 14 | (36.8) | |||
| Smoker | 53 | 37 | (69.8) | 13 | (24.5) | 0.1 | -- | -- | |||
Parameters: Normal vs dysplasia : acytoplasmic slug , bNuclear slug ,Chi Square analysis Grade of dysplasia: ccytoplasmic slug , dNuclear slug, Chi Square trend analysis Dysplasia vs. ESCC: : ecytoplasmic slug , fNuclear slug ,Chi Square analysis Normal vs. ESCC: : gcytoplasmic slug , hNuclear slug ,Chi Square analysis