Table 1. Case detection, total cohort cost and costs per patient diagnosed for Xpert-for-all and 3 example triage pathways.

Algorithm and scenarios	Cohort	Number of persons in Cohort with TB	Total TB cases detected	% of TB cases	Cohort Diagnostic Costs (US$2011)	Reduction in cohort diagnostic cost	Diagnostic cost per TB case detected (US$ 2011)	Treatment Costs (US$ 2011)	Total Costs ($2011)	Reduction in total cost	Total cost per TB case detected (US$ 2011)
UGANDA
Xpert for all persons with presumptive TB
	Tuberculosis (all)	959	912	95%	195294	Baseline	214	213602	408895	Baseline	448
	No Tuberculosis	9041
	MDR TB	18	16	90%
Triage example 1. 100% sensitivity, 75% specificity, cost $5; if positive followed by Xpert.
	Tuberculosis (all)	959	912	95%	112368	42%	123	200643	313012	23%	343
	MDR TB	18	16	90%
Triage example 2. 95% sensitivity, 75% specificity, cost $5
	Tuberculosis (all)	959	895	93%	112204	43%	125	197046	309250	24%	345
	MDR TB	18	16	88%
Triage example 3. 85% sensitivity, 85% specificity, cost $5
	Tuberculosis (all)	959	853	89%	94299	52%	111	186160	280460	31%	329
	MDR TB	18	15	84%
INDIA
Xpert for all persons with presumptive TB
	Tuberculosis (all)	695	684	99%	141835	Baseline	207	273885	415720	Baseline	607
	No Tuberculosis	9305
	MDR TB	36	33	93%
Triage example 1. 100% sensitivity, 75% specificity, cost $5; if positive followed by Xpert.
	Tuberculosis (all)	695	684	99%	93458	34%	137	255064	348521	16%	509
	MDR TB	36	33	93%
Triage example 2. 95% sensitivity, 75% specificity, cost $5
	Tuberculosis (all)	695	677	97%	93487	34%	138	252267	345754	17%	511
	MDR TB	36	33	92%
Triage example 3. 85% sensitivity, 85% specificity, cost $5
	Tuberculosis (all)	695	653	94%	80373	43%	123	241119	321493	23%	492
	MDR TB	36	32	89%
SOUTH AFRICA
Xpert for all persons with presumptive TB
	Tuberculosis (all)	956	910	95%	174726	Baseline	192	811040	985767	Baseline	1083
	No Tuberculosis	9044
	MDR TB	92	82	90%
Triage Example 1. 100% sensitivity, 75% specificity, cost $5; if positive followed by Xpert.
	Tuberculosis (all)	956	910	95%	107272	39%	118	771254	878526	11%	965
	MDR TB	92	82	90%
Triage example 2. 95% sensitivity, 75% specificity, cost $5
	Tuberculosis (all)	956	893	93%	107103	39%	120	757378	864481	12%	968
	MDR TB	92	81	88%
Triage example 3. 85% sensitivity, 85% specificity, cost $5
	Tuberculosis (all)	956	851	89%	91207	48%	107	716733	807940	18%	949
	MDR TB	92	77	84%

% prevalence of smear-positive TB. For a cohort of 10 000 persons with presumptive TB with 5

 =  multi-drug resistant tuberculosis. MDR TB

 =  GeneXpert MTB/RIF assay. Xpert