Table 2. Total cohort cost, DALYS, cost per DALY and ICER for Xpert on all compared to triage pathways as the base case.

Country	Algorithm and scenarios	Total Costs ($2011)	Incremental Costs	Total DALYS	Incremental DALYs averted	Cost per DALY averted	ICER of Xpert-forall, compared to the triage pathway example	Monte Carlo Simulation ICER, Median (2.5, 97.5)*
Uganda	Triage; if positive followed by Xpert.
	Example 2. 95% sensitivity, 75% specificity, cost $5	309250		12102		26	base case
	Xpert for all persons with presumptive TB	408895	99646	12306	203	33	491	487 (392, 597)
	Example 3. 85% sensitivity, 85% specificity, cost $5	280460		11566		24	base case
	Xpert for all persons with presumptive TB	408895	128436	12306	740	33	174	173 (144, 206)
India	Triage; if positive followed by Xpert.
	Example 2. 95% sensitivity, 75% specificity, cost $5	345754		9904		35	base case
	Xpert for all persons with presumptive TB	415720	69966	10009	106	42	662	672 (541, 833)
	Example 3. 85% sensitivity, 85% specificity, cost $5	321493		9568		34	base case
	Xpert for all persons with presumptive TB	415720	94228	10009	442	42	213	216 (179, 260)
South Africa	Triage; if positive followed by Xpert.
	Example 2. 95% sensitivity, 75% specificity, cost $5	864481		10176		85	base case
	Xpert for all persons with presumptive TB	985767	121286	10351	175	95	695	695 (575, 836)
	Example 3. 85% sensitivity, 85% specificity, cost $5	807940		9719		83	base case
	Xpert for all persons with presumptive TB	985767	177827	10351	632	95	281	282 (240, 330)

% prevalence of smear-positive TB. For a cohort of 10 000 persons with presumptive TB with 5

 = incremental cost-effectiveness ratio. ICER

 = disability adjusted life year. DALY

 =  multi-drug resistant. MDR

 =  GeneXpert MTB/RIF assay. Xpert

Fixed values for the sensitivity, specificity and cost of the triage test.