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. 2013 Dec 11;11:304. doi: 10.1186/1479-5876-11-304

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Copyright © 2013 Sheinerman et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Differentiation of GI pathologies fromPS pathologies by miRNA biomarker pairs. The concentrations of miRNAs in plasma samples from patients with GI pathologies (40 patients total) and pulmonary system pathologies (30 patients total) were measured by RT-qPCR and the ratios of various miRNAs were calculated as 2^-ΔCq x100. A, B – box-plots. C, D –ROC curves for differentiation between patients with the four GI and the three pulmonary system (PS) pathologies obtained with different biomarker pairs. All statistical analyses are performed as in Figure 1. E, F – 2D-graphs comparing biomarker miRNA pairs from A, C and B, D, respectively.