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. 2013 Dec 11;11:304. doi: 10.1186/1479-5876-11-304

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Copyright © 2013 Sheinerman et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Differentiation of all cancers from all inflammatory pathologies by miRNA biomarker pairs. The concentrations of miRNAs in plasma samples from patients with cancers of four organs (40 patients total) and three inflammatory diseases (30 patients total) were measured by RT-qPCR and the ratios of various miRNAs were calculated as 2^-ΔCq x 100. A, B – box-plots. C, D – Receiver-Operating Characteristic (ROC) curves of differentiation between patients with cancers of the four organs and patients with any of the three inflammatory diseases obtained with different biomarker pairs. All statistical analyses are performed as in Figure 1. E, F – 2D-graphs comparing biomarker miRNA pairs from A, C and B, D, respectively.