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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Acta Biomater. 2013 Aug 9;9(12):10.1016/j.actbio.2013.08.002. doi: 10.1016/j.actbio.2013.08.002

Fig. 6.

Fig. 6

Calcium alginate gels induce greater inflammatory cytokine secretion compared to barium alginate gels and enhanced LPS-induced inflammation in vivo. (A) 50 μl of barium (4 mM) and calcium (48.8 mM) alginate gels were injected into subcutaneous tissue of mice. At various timepoints, alginate gels were removed and analyzed for [Ca2+]. (B) 50 μl of barium and calcium alginate gels, with or without LPS, were injected into mice. After 24 h, gels were harvested and analyzed for IL-1β concentration and (C) other inflammatory cytokines and chemokines. Asterisks indicate that the condition is significantly different from the barium only condition. *P < 0.05.