Table 2. Analysis of persistence in therapy: continuation of therapy (DDD duration) for the recommended period of time.
| GAP | Type | No. | Min | ASL associated with min | Max | ASL associated with max | Mean Diff. | SD | CI 95% Low. Lim. | CI 95% Upp. Lim. | p-value | |
| Metformin | 90 days | Branded | 6410 | 305.7 | Milano city | 435.5 | Lecco | 67.23 | 6.56 | 54.38 | 80.08 | <0.0001 |
| A10BA02 | Generic | 7688 | 254.3 | Lecco | 508.4 | Melegnano | ||||||
| Amlodipine | 90 days | Branded | 11435 | 367.8 | Milano city | 441.9 | Bergamo | 78.69 | 6.74 | 65.47 | 91.91 | <0.0001 |
| C08CA01 | Generic | 5101 | 441.6 | Milano city | 535.5 | Bergamo | ||||||
| Simvastatin | 90 days | Branded | 6355 | 281.15 | Milano city | 365.2 | Melegnano | 79.79 | 5.89 | 68.25 | 91.33 | <0.0001 |
| C10AA01 | Generic | 10133 | 348.7 | Milano city | 428.1 | Melegnano | ||||||
| Sertraline | 30 days | Branded | 3822 | 144.9 | Milano city | 183.1 | Melegnano | 23.48 | 5.21 | 13.28 | 33.68 | <0.0001 |
| N06AB06 | Generic | 3176 | 119.2 | Lecco | 231.7 | Melegnano | ||||||
| Propafenone | 30 days | Branded | 805 | 197.1 | Milano city | 291.9 | Bergamo | 9.07 | 21.08 | −32.24 | 50.39 | N.S. |
| C01BC03 | Generic | 328 | 137.5 | Lecco | 274.0 | Bergamo | ||||||
| Alendronate | 60 days | Branded | 1821 | 281.4 | Pavia | 369.1 | Melegnano | 41.07 | 11.66 | 18.22 | 63.91 | 0.0004 |
| M05BA04 | Generic | 1605 | 328.1 | Milano city | 401.1 | Lecco |
DDD: Defined Daily Dose.
ASL: Local Healthcare Units. ASLs enrolled: Milano city; Lecco; Bergamo; Pavia; Milano2.
GAP: The maximum time intervals between two deliveries; “maximum allowed gaps”.
N.S. not statistically significant.