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. 2013 Dec 18;8(12):e83300. doi: 10.1371/journal.pone.0083300

Figure 4. PPARβ promotes the initiation of differentiation at gastrulation.

Figure 4

(A) Rationale of the transcriptomic analysis of PPARβ loss-of-function. (B) The gene set consisting of predicted direct PPAR target genes in humans [33] was analysed by GSEA. (C) The Gene Ontology terms or the gene sets that were significantly (FDR<0.2) affected by PPARβ loss-of-function are presented. The gene sets corresponding to germ layer specification are also presented. (D) The gene sets consisting of the 100 most-induced genes and of the 100 most-decreased genes at gastrula (see also Fig. S5) were analysed by GSEA. FDR, false discovery rate; GSEA, Gene Set Enrichment Analysis; NES, Normalized enrichment score.