Table1. Tight junction proteins in peripheral nerve.
| First trimester | Second trimester | Third trimester | Adult human | Adult rodent | |
|---|---|---|---|---|---|
| Blood vessels: pericytes and endothelial cells |
Cl−5.22 |
Cl−5.22 |
Cl−5.22 |
Cl−522 |
CL-562 |
| Perineurium: perineurial cells |
Cl−1*, Cl−3*.22 |
Cl−1, Cl−3, ZO-1*, Occl*.22 |
Cl−1, Cl−3, Occl, ZO-1.22 |
Cl−1, Cl−3, Occl, ZO-1.22 |
Cl−1, Occl.54 |
| Endoneurium: Paranodal region |
Undetectable spots.44 |
CL-1*, Cl−3*, Occl*, ZO-1.44 |
CL-1*, Cl−3*, Occl*, ZO-1.44 |
Cl−1, Cl−2, Occl, ZO-1.44 |
Cl−1, Cl−2, ZO-1.37 Cl−19.38 Tric.43 |
| Endoneurium: Schmidt-Lanterman |
Undetectable spots.44 |
CL-1*, Cl−3*, Occl*, ZO-1.44 |
CL-1*, Cl−3*, Occl*, ZO-1.44 |
Cl−1, Cl−2, Cl−3, Cl−5, Occl, ZO-1.44 |
Cl−5, ZO-1.37 Cl−19.38 Tric.43 |
| Endoneurium: Mesaxons |
Undetectable spots.44 |
Cl−3*, Occl* |
Cl−3, Occl* |
Cl−1, Cl−2, Cl−3, Occl, ZO-1 |
Cl−1, ZO-1.37 Cl−19.38 Tric.43 |
| Endoneurium: Node of Ranvier | -.44 | -.44 | -.44 | -.44 | Cl−2.37 |
*
immature labeling pattern; Occl, occludin; Tric, tricellulin.