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. Author manuscript; available in PMC: 2013 Dec 18.
Published in final edited form as: J Cell Biochem. 2012 Jan;113(1):10.1002/jcb.23333. doi: 10.1002/jcb.23333

Figure 6. A mechanism detailing the role of FOXA1 in IGF-I Activity.

Figure 6

IGF-I treatment of MCF7 cells leads to an increase in the half-life of FOXA1 protein, via activation of MAPK and AKT. FOXA1 is also a crucial component of the IGF-I-mediated regulation of target genes as well as IGF-I-induced cellular proliferation and cell survival.