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. 2013 Sep 30;5(1):31–48. doi: 10.1002/wrna.1195

Figure 4.

Figure 4

Proposed catalytic pathway for ribonuclease III (RNase III). The diagram is a modification of a proposed scheme.31,39 Initial recognition of dsRNA (black) by a dsRBD (pink) is followed by engagement of the RNase III domain (light blue) and the second dsRBD to form a precatalytic complex. Phosphodiester hydrolysis (red arrows) provides a post-catalytic complex with products still bound by the RNase III domain. Release of the products from the RNase III domain is followed by release from the dsRBDs. The rate-limiting step may be release of products from the RNase III domain (see text). (Reprinted with permission from Ref 7. Copyright 2011 Springer Science+Business Media).