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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: J Neurochem. 2013 Aug 21;128(1):10.1111/jnc.12380. doi: 10.1111/jnc.12380

Figure 3.

Figure 3

Immunohistochemistry reveals weak Ob-Rb localization to neuronal cytoplasm in pyramidal neurons of control individuals (A) as well as the occasional age-related neurofibrillary tangles (A, arrow). In the AD cases examined, however, NFT are prominently labeled (B) both intracellullar and extracellular NFT (marked by * in B). The NFT exhibits typical fibrillar morphology (C). Ob-Rb is also colocalized with the neuritic pathology associated with senile plaques (D). Adsorption with the peptide antigen nearly abolishes the NFT and neuritic plaque localization (E) compared to the non-absorbed adjacent sections (F). Scale bars = 50 μm (A,B,D-F) and 20 μm (C).