Table 4.

Indicating average weights of ten top important features computed by MCRLR in the jackknife procedure using all of features for prediction of five RNA-binding domain subclasses. Positive values show preference of the features in related subclasses and negative values show avoidance of the features in related subclasses.

No.	Feature/Average Value
	7s RBD subclass	Double -stranded RBD subclass	mRNA RBD subclass	rRNA RBD subclass	tRNA RBD subclass
1	Number of Met in MP/1.517	Number of basic AAs in MP/0.967	Molecular weight/1.373	Number of His in MP/1.913	Number of Arg in IR/2.004
2	Number of Met in RC/1.274	Number of Glu in MP/0.900	Number of Ser in BR/1.176	Number of Arg in IR/-1.555	Number of His in sheet/2.003
3	Number of Cys in sheet/0.998	Dipole/0.900	Number of Cys in MP/1.142	Number of Ile in MP/1.499	Number of Pro in MP/-1.583
4	Number of His in seq./-0.920	Number of Glu in IR/0.891	Number of Ser in IR/-1.094	Number of Leu in helix/-1.481	Number of Ile in MP/-1.576
5	Number of Met in ER/0.990	Number of Tyr in MP/0.831	Isoelectric point/-1.007	Number of Met in RC/-1.458	Number of Asp in BR/1.371
6	Number of Glu in MP/-0.886	Number of Ala in BR/0.811	Number of Cys in RC/0.969	Number of Ser in RC/1.330	Number of Ile in IR/-1.335
7	Number of Tyr in helix/0.811	Number of Gln in RC/-0.799	Number of charged AAs in seq./-0.949	Number of Tyr in MP/-1.304	Number of Met in sheet/1.255
8	Number of Glu in IR/0.759	Number of Arg in MP/-0.779	Number of Asp in ER/0.934	Number of Val in helix/1.280	Number of Phe in ER/-1.226
9	Frequency of antiparallel HB/-0.753	Number of Lys in MP/0.752	Number of Arg in ER/-0.931	Number of His in ER/-1.269	Number of Phe in IR/1.166
10	Second patch size/-0.729	Number of Asp in MP/0.728	Number of Asp in IR/0.920	Number of Cys in RC/-1.258	Number of Gln in IR/1.114

MP: main patch, RC: randomcoil, ER: exposed regions, IR: intermediate regions, HB: hydrogen bond, AAs: amino acids, BR: buried regions, Seq.: Sequence.