Table 1.
Biomarker candidates of androgen dependency loss
| Protein name | Protein ID | Number of identified peptides (based on MS/MS spectra) | Average score | Standard deviation | Present antigen |
|---|---|---|---|---|---|
| TLN1_HUMAN talin-1 | Q9Y490 | 9 | 437 | 53 | Antennary N-glycan |
| ITA9_HUMAN integrin α-9 precursor | Q13797 | 7 | 359 | 64 | Tn |
| 1433T_HUMAN 14-3-3 protein θ | P27348 | 8 | 397 | 51 | Tn |
| 1433B_HUMAN 14-3-3 protein β/α | P31946 | 5 | 285 | 46 | Tn |
| 1433G_HUMAN 14-3-3 protein γ | P61981 | 8 | 275 | 62 | Tn |
| 1433Z_HUMAN 14-3-3 protein ζ/δ | P63104 | 6 | 212 | 54 | Tn |
| TBB4_HUMAN tubulin β-4 chain | Q13509 | 10 | 417 | 61 | Tn |
| TBB1_HUMAN tubulin β-1 chain | Q9H4B7 | 7 | 391 | 59 | Antennary N-glycan |
| MYH10_HUMAN myosin-10 | P35580 | 11 | 326 | 73 | Tn/antennary N-glycan |
| ACTZ_HUMAN α-centractin (centractin) | P61163 | 6 | 237 | 62 | Tn |
| ACTC_HUMAN actin, α cardiac muscle | P68032 | 5 | 178 | 73 | Tn |
| EF1A2_HUMAN elongation factor 1-α 2 | Q05639 | 4 | 183 | 56 | Tn |
| EF1B_HUMAN elongation factor 1-β | P24534 | 7 | 283 | 49 |
Antennary N-glycan |
| EF1G_HUMAN elongation factor 1-γ | P26641 | 6 | 219 | 65 | Tn |
| COFA1_HUMAN collagen α-1(XV) chain precursor | P39059 | 6 | 290 | 54 | Tn |
| CO5A2_HUMAN collagen α-2(V) chain | P05997 | 4 | 146 | 69 | Tn |
| AT1A2_HUMAN sodium/potassium-transporting ATPase α-2 | P50993 | 4 | 119 | 76 | Tn |
| ATPO_HUMAN ATP synthase subunit O | P48047 | 5 | 89 | 36 | Tn |
| VDAC3_HUMAN voltage-dependent anion-selective channel protein 3 | Q9Y277 | 4 | 164 | 55 | Tn |
| G6PI_HUMAN glucose-6-phosphate isomerase | P06744 | 5 | 183 | 63 | Tn |
| PGM2_HUMAN phosphoglucomutase-2 | Q96G03 | 6 | 192 | 68 | Tn |
| KCRB_HUMAN creatine kinase B-type | P12277 | 6 | 117 | 53 | Tn/antennary N-glycan |
| VDP_HUMAN general vesicular transport factor p115 | O60763 | 5 | 192 | 49 | Tn |
| EEA1_HUMAN early endosome antigen 1 | Q15075 | 5 | 162 | 62 |
Antennary N-glycan |
| ROA1_HUMAN heterogeneous nuclear ribonucleoprotein A1 | P09651 | 7 | 183 | 69 |
Antennary N-glycan |
| RU2A_HUMAN U2 small nuclear ribonucleoprotein A’ | P09661 | 5 | 127 | 49 | Tn |
| HNRH1_HUMAN heterogeneous nuclear ribonucleoprotein H | P31943 | 6 | 182 | 37 | Tn |
| HNRPF_HUMAN heterogeneous nuclear ribonucleoprotein F | P52597 | 7 | 172 | 53 | Tn |
| RL7_HUMAN 60S ribosomal protein L7 | P18124 | 5 | 128 | 59 | Tn |
| NUCL_HUMAN nucleolin | P19338 | 8 | 371 | 33 | Tn |
| RL13_HUMAN 60S ribosomal protein L13 | P26373 | 6 | 219 | 58 | Tn |
| IF39_HUMAN eukaryotic translation initiation factor 3 subunit 9 | P55884 | 4 | 163 | 38 | Tn |
| RT07_HUMAN 28S ribosomal protein S7 | Q9Y2R9 | 4 | 149 | 49 | Tn |
| YBOX1_HUMAN nuclease-sensitive element-binding protein 1 | P67809 | 6 | 238 | 40 | Tn |
| UGDH_HUMAN UDP-glucose 6-dehydrogenase | O60701 | 4 | 217 | 58 | Tn |
| ACADV_HUMAN very long-chain specific acyl-CoA dehydrogenase | P49748 | 5 | 173 | 53 |
Antennary N-glycan |
| ASPH_HUMAN aspartyl/asparaginyl beta-hydroxylase | Q12797 | 4 | 115 | 46 | Tn |
| NQO1_HUMAN NAD(P)H dehydrogenase (quinone) 1 | P15559 | 3 | 93 | 38 |
Antennary N-glycan |
| PKHA5_HUMAN pleckstrin homology domain-containing family A member 5 | Q9HAU0 | 4 | 72 | 39 | Tn |
| NPC1_HUMAN niemann-pick C1 protein | O15118 | 5 | 81 | 53 |
Antennary N-glycan |
| IQGA1_HUMAN ras GTPase-activating-like protein IQGAP1 | P46940 | 3 | 148 | 58 |
Tn/antennary N-glycan |
| RAB8A_HUMAN ras-related protein Rab-8A | P61006 | 4 | 219 | 64 | Tn |
| RAB8B_HUMAN ras-related protein Rab-8B | Q92930 | 6 | 246 | 38 | Tn |
| RAN_HUMAN GTP-binding nuclear protein Ran | P62826 | 4 | 173 | 46 | Tn |
| PSMD5_HUMAN 26S proteasome non-ATPase regulatory subunit 5 | Q16401 | 3 | 116 | 58 | Tn |
| IMB3_HUMAN importin β-3 | O00410 | 6 | 82 | 47 | Tn |
| PHB_HUMAN prohibitin | P35232 | 7 | 412 | 46 | Tn |
| COMT_HUMAN catechol O-methyltransferase | P21964 | 4 | 184 | 39 | Tn |
| TGM2_HUMAN protein-glutamine γ-glutamyltransferase 2 | P21980 | 3 | 94 | 64 | Antennary N-glycan |
Average score was calculated based on three biological and two technical replicates