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. 2013 Dec 19;7:93. doi: 10.3389/fnint.2013.00093

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Copyright © 2013 Melis, De Felice, Lecca, Fattore and Pistis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of MAGL inactivation on CB1 receptor function in female LH rats. (A) Bar graphs showing the effect of MAGL inhibitor JZL184 on the amplitude of rostral (left panel) and caudal (right panel) GABA_A IPSCs in female and male LH rats is plotted. GABA_A IPSCs amplitude was normalized to the averaged value (dotted line) before JZL184/vehicle bath application. (B) Dose–response curves for percentage inhibition in GABA_A IPSC amplitude, which were recorded in female LH rats from VTA DA cells and evoked by stimulating either rostral (left panel, n = 6 for both sexes) or caudal (right panel, n = 6 for both sexes) afferents, produced by WIN in the presence (gray squares) or absence (red circles) of JZL184. Each symbol represents the averaged value ( ± SEM) obtained from different cells. GABA_A IPSCs amplitude was normalized to the averaged value (dotted line) before drug application. *P < 0.05, **P < 0.01.