Table 1.

Reliability and sample size estimation of neurogenic inflammation assessment methods in the human UVB model. The intra-class correlation coefficient (ICC) and coefficient of variation (CV) were calculated within the 3 consecutive days after one UVB irradiation as well as between two UVB irradiations separated by two weeks. The sample size was estimated for crossover and parallel designed drug studies. Neurogenic inflammation was assessed as erythema, skin temperature and superficial blood flow (sBF) inside and outside the irradiated area

	Within UVB irradiation		Between UVB irradiation		Estimated Sample Size
	ICC	CV (%)	ICC	CV (%)	Crossover	Parallel
Erythema index	0.50	6	0.63	4	4	6
Skin Temperature	0.43	2	0.38	2	73	134
sBF inside irradiated area	0.29	20	0.35	19	15	20
sBF outside irradiated area	0.31	22	-0.05	23	6850	10230