Figure 3.

Concentration-dependent decrease in NO release from trigeminal SGCs after treatment with Ibu and Vit D₃. FSK stimulation facilitated a pronounced and significant increase in the NO release from the SGCs, which could be completely or partially reversed by co-treatment with the Ibu and Vit D₃ (A, B). Data are presented as mean ± SEM (n = 5). *, p < 0.05; **, p < 0.01 vs. vehicle; #, p < 0.05; ###, p ≤ 0.001 vs. FSK. FSK, Forskolin; Ibu, Ibudilast; Vit D₃, 1α,25-dihydroxyvitamin D₃; SGCs, Satellite Glial Cells.