Figure 4.
Analysis of conservation of sequences surrounding the polyadenylation site of the human ASS1 gene. Sequences equivalent to the human reference sequence hg18, chr9: 132,366,435-132,366,576 are displayed. Two measurements of evolutionary conservation are shown where Primate Conservation is derived from 9 primate species; Mammals Conservation is restricted to the placental mammals including 24 species. Shown below the conservation measurements are sequence alignments of human and the specified species. Double dashes indicate that the aligned species has one or more unalignable bases in the gap region. The pA1prox and pA1dist hexamer sequences and the downstream U-rich elements (U1, U2 and U3) and GU-repeats are boxed. The images are taken from the UCSC Genome Browser website (http:genome.ucsc.edu/).