Table 2.
Association of Individual NBN Polymorphisms and Cancer Risk
| Population | n° cases | n° controls | Polymorphisms and association (OR) reported as significant |
References | |
|---|---|---|---|---|---|
| Basal Cell Carcinoma |
Caucasian Caucasian |
241 529 |
574 533 |
No (rs1805794) 2.19 Men (rs1805794CC), No women (rs1805794) |
[72] [73] |
| Bladder | Caucasian Caucasian Mixed |
299 1086 771 |
278 1020 800 |
1.64 (rs1805794 CC) No (rs1063045, rs1805794, rs867185, rs1063053) No (rs14448, rs9995, rs13312986, rs1063054, rs133312981, rs2735383, rs1063053) |
[82] [89] [90] |
| Breast | Caucasian Caucasian Afroamerican Caucasian Chinese Caucasian Afroamerican Caucasian Caucasian Taiwanese Non-hispanic Caucasian |
2205 223 766 1273 220 336 63 97 289 559 421 |
1826 319 681 1136 310 416 78 74 548 1125 423 |
No (rs1063045, rs1805794, rs709816, rs1061302) No (rs1805794) No (rs1805794) No (rs1805794) No (rs1805794) No (rs1805794) Significant trend (rs1805794) No (rs1805794), 3.4 (rs36226237) No (rs1805794) No (rs1805794) No (rs1805794, rs1061302, rs1063045), 1.2 (rs1805790 GG) 1.3 (rs1805794 GG) 1.83 (rs1805794 CC), 4.5 (rs924 CC) |
[100] [102] [101] [101] [103] [104] [104] [105] [95] [106] [107] |
| Colorectal | Caucasian | 532 | 532 | No (rs1805794) | [111] |
| Head and Neck | Caucasian Chinese |
175 1052 |
275 1168 |
No (rs1063045, rs2234744, rs709816, rs1061302, rs3736639) 1805794GC lower in laryngeal cancer No (rs2735383)1.7 (rs1805794 CC) 3.7 (rs1805794 GC) East China No (rs2735383)1.5 (rs1805794CC) 3.9 (rs1805794GC) South China |
[116] [126] |
| Hepatic Cancer | Chinese | 865 | 900 | 1.4 (rs1805794 GC) 2.27 (rs1805794 CC) No (rs2735383) |
[132] |
| Leukaemia | Caucasian Chinese Chinese |
157 175 428 |
275 360 600 |
No (rs1063045, rs1805794, rs709816, rs1061302, rs2234744) 1.8 (rs376639 TT) 3.4 (rs1805794 CC), No (rs2735383) 1805794 CC as reference GG e GC were associated with decreased risk of cancer, No (rs2735383) |
[148] [65] [149] |
| Lymphoma | NI Mixed Mixed |
91 797 200 |
154 793 220 |
No (rs1063045, rs1805794, rs2234744, rs709816, rs1061302, rs2308962) No (rs13312842, rs36226237, rs1805796, rs1063053, rs1063045, rs1805794, rs1061302) No (rs1805794) |
[28] [145] [146] |
| Lung | Mixed Chinese Caucasian Caucasian |
611 1559 343 177 |
1040 1679 413 154 |
1.6 (rs1061302GG), 1.6 (rs1063054) No (rs14448,13312986) 1.4 (rs2735383 CC recessive model) 1.7 (rs2735383 CC recessive model for never smokers) No (rs1805794) 2.2 non-smoking women, 1.5 low-dose smoking women (rs 805794) |
[160] [64] [199 [200] |
| Medulloblastoma | NI | 42 tumor samples | - | No (rs1063045, rs709816, rs1061302, rs1805794, rs2234744, rs1805818, rs2308962, rs3736640) | [168] |
| Melanoma | Caucasian | 632 | 615 | No (rs9995, rs867185, rs1063045) | [37] |
| Ovarian | Caucasian | 643-732 | 1246-1695 | No (rs1063045, rs1805794, rs769420, rs1061302) | [182] |
| Prostate | Caucasian Caucasian |
200 239 early cancer 186 advanced cancer |
200 NI |
No (rs1805794) No (rs1805794) 1.8 (rs1805794 GG) |
[57] [186] |
| Renal Cell Carcinoma |
Caucasian | 326 | 335 | 2.13 (rs1805794 CC) | [190] |
| Thyroid Cancer | Caucasian | 109 | 217 | No (rs1805794) | [191] |
Abbreviations: NI: not indicated; No: no significant association found; OR: odds ratio.