Table 2.

Human Traits / Diseases Showing Association with Polymorphisms in Traditional PCSK Genes in Large Genetic Studies

Gene	Disease / Trait	Reference
PCSK1	Fasting glucose-related traits	[52]
	Body mass index	[71]
	Proinsulin levels	[64]
	Age at natural menopause	[73]
	Proinsulin conversion, glucose homeostasis	[67]
	Body mass index and overweight in men	[70]
	Obesity	[59, 72]
PCSK2	Dialysis-related mortality	[99]
	Age at onset of menarche	[101]
	Fibrinogen level	[102]
	Total antioxidant level	[96]
	Amyotrophic lateral sclerosis	[103]
	Maximum common carotid intimal medial thickness	[100]
	Chronic kidney disease	[98]
FURIN	Blood pressure	[115]
	Hypertension	[114]
	HPV infection outcome	[111]
PCSK4	no large genetic association studies reported
PCSK5	Age at onset of amyotrophic lateral sclerosis	[126]
	Total ventricular volume	[125]
	Height	[130]
	Behavioral skills in children that have undergone cardiac surgery	[124]
	HDL levels	[128]
PCSK6	Handedness in dyslexia	[131]
	Blood pressure	[137]
PCSK7	Cardiovascular-related traits	[152]
	Iron homeostasis	[148]