Figure 2.

[¹⁸F]FLT uptake is a sensitive measure for Sorafenib treatment of A673 cells in vitro. A673 cells were treated with the indicated concentrations of Sorafenib for 48 h or with doxorubicin for 24 h. A: Cellular [¹⁸F]FLT (left panel) and [¹⁸F]FDG (right panel) -uptake measurements (gamma-counter in counts per minute, cpm) performed as described in the material and methods section 48 hours after treatment with the indicated concentration of Sorafenib. B: Cellular [¹⁸F]FLT (left panel) and [¹⁸F]FDG (right panel) -uptake measurements 24 hours after treatment with the indicated concentration of doxorubicin. Shown are the mean values ± SD of n=3 individual experiments.