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. 2013 Dec 19;5:93. doi: 10.3389/fnagi.2013.00093

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Copyright © 2013 Roussotte, Gutman, Hibar, Jahanshad, Madsen, Jack, Weiner and Thompson, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI).

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of the A allele at the rs26907 locus in the RASGRF2 gene, on regional brain volumes in the ADNI1 (top panel) and ADNI2 (bottom panel) cohorts. Positive beta values (warm colors) show regions where the minor A allele was associated with greater tissue volumes. Negative beta values (cool colors) show regions where the minor A allele was associated with lower tissue volumes. The color bar encodes the average percentage of volume difference relative to the template associated with the minor allele. Tests for associations are adjusted for age, sex, and diagnosis; maps are corrected for multiple comparisons with the searchlight false discovery rate (FDR) method at q = 0.05. Images are in radiological convention (left side of the brain shown on the right).