Table I.
Regulators of IL-17 signaling
| Name | Description | Reference |
|---|---|---|
| Negative | ||
| TRAF4 | Competes with TRAF6 for Act1 binding | [57] |
| TRAF3 | Binds to the IL-17R to interfere with the formation of the IL-17R-Act1-TRAF6 complex | [58] |
| USP25 | Restricts the ubiquitination of TRAF5 and TRAF6 to down-regulate IL-17 signaling and mRNA stabilization | [61] |
| A20 | Interacts directly with the distal domain of IL-17RA and mediates deubiquitination of TRAF6 | [62] |
| C/EBPβ | Becomes phosphorylated by ERK and Gsk-3β and inhibit the expression of IL-17 target genes | [60] |
| miR23b | Inhibits IL-17 induced NFκB activation | [63] |
| IL-17RD | Disrupts the interaction of Act1 and TRAF6 to inhibit NFκB activation | [67, 68] |
| Positive | ||
| NFκBIZ | Required for IL-17A induced gene expression | [65, 66] |
| IL-17RD | Enhances IL-17A-dependent MAPK signaling and neutrophil recruitment through MIP-2 | [67, 68] |
| C/EBPδ | Essential for IL-27-dependent IL-6 expression | [156] |