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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Hypertension. 2013 Aug 19;62(4):10.1161/HYPERTENSIONAHA.113.01846. doi: 10.1161/HYPERTENSIONAHA.113.01846

Figure 5. Role of CTGF in TGF response in WKY and SHR fed normal salt diet.

Figure 5

In rats fed a normal salt diet (NSD), two TGF responses were elicited, first in the presence of CTGF (○, vehicle), then during inhibition of CTGF (●, benzamil 1μM). Inhibition of CTGF potentiated the TGF response in WKY (Panel A) but not in SHR (Panel B). Panel C: SHR (closed bars) tended to have a smaller CTGF response compared to WKY (open bars). P < 0.01 for the overall comparison between strains (ANOVA) and P < 0.05 at the 30 and 40 nL/min perfusion rates, but not statistically significant after adjustment for multiple comparisons.