Figure 3. TGFβ-responsive genes are deregulated in the “diffuse-proliferation” subset of scleroderma.
(a) Intrinsic subsets of scleroderma as described by Milano et al. (2008). (b) Organization of 75 arrays from Milano et al. by hierarchical clustering of 894 TGFβ-responsive signature genes. Shading is indicative of positioning of subsets identified by intrinsic genes relative to that identified by the TGFβ-responsive signature. *P < 0.001.