Table 3.
Cytotoxic activity (IC50 values) of G. bicolor extracts against selected human cell lines.
| Extract |
Treatment duration (hour) |
Cytotoxicity (IC50) in µg/mL | ||||||
|---|---|---|---|---|---|---|---|---|
| HT-29 | HCT 116 | HCT-15 | SW480 | Caco-2 | MCF7 | CCD-18Co | ||
| Methanol | 24 | >100 | >100 | >100 | >100 | >100 | >100 | >100 |
| 48 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | |
| 72 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | |
|
| ||||||||
| Hexane | 24 | >100 | >100 | >100 | >100 | >100 | >100 | >100 |
| 48 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | |
| 72 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | |
|
| ||||||||
| Ethyl acetate | 24 | 39.7 ± 1.7 | 16.0 ± 4.5 | 12.8 ± 5.3 | 26.3 ± 1.2 | 32.7 ± 1.5 | 36.5 ± 3.4 | >100 |
| 48 | 49.5 ± 8.6 | 20.9 ± 0.2 | 18.7 ± 1.9 | 31.7 ± 5.7 | 46.3 ± 8.7 | 34.8 ± 0.8 | >100 | |
| 72 | 37.3 ± 2.5 | 29.2 ± 0.9 | 21.2 ± 1.2 | 47.8 ± 3.6 | 55.2 ± 6.4 | 46.3 ± 4.2 | >100 | |
|
| ||||||||
| Water | 24 | >100 | >100 | >100 | >100 | >100 | >100 | >100 |
| 48 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | |
| 72 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | |
|
| ||||||||
| Cis-platin* | 24 | >12.5 | 12.0 ± 0.7 | 6.2 ± 0.4 | >12.5 | >12.5 | 11.2 ± 0.5 | >12.5 |
| 48 | 10.1 ± 0.2 | 4.0 ± 0.3 | 3.9 ± 0.2 | 6.8 ± 0.5 | 4.3 ± 0.4 | 4.2 ± 0.4 | >12.5 | |
| 72 | 6.4 ± 0.6 | 2.9 ± 0.1 | 1.7 ± 0.4 | 3.2 ± 0.6 | 1.9 ± 0.2 | 2.7 ± 0.3 | >12.5 | |
*Positive reference standard. Values are expressed as mean ± standard deviation (n = 3).