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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Medchemcomm. 2013 Oct 15;4(12):10.1039/C3MD00238A. doi: 10.1039/C3MD00238A

Scheme 1.

Scheme 1

Total synthesis of anziaic acid: Reagents and conditions: (a) DMF, POCl3, 0 °C to rt, 56%; (b) BnBr, K2CO3, acetone, reflux, 70%; (c) NaClO2, NaH2PO4, DMSO/H2O, 61% (3) and 50% (4); (d) Pd/C, H2, ethyl acetate, 97%; (e) BnBr, KHCO3, DMF, 92%; (f) (CF3CO)2O, toluene, 64%; (g) Pd/C, H2, ethyl acetate, 95%.