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. 2013 Sep 10;4(12):1537–1548. doi: 10.1021/cn400133s

Figure 2.

Figure 2

Cognitive behavior in gonadectomized 3xTg-AD mice treated with SARM/ERβ agonists for a 4-month period. (A) Learning curve demonstrating all groups of mice learned to find the hidden platform in the MWM over 6 days (p < 0.0001). (B) Analysis of the probe trial: No significant difference between the groups in the frequency in the platform quadrant. (C) Latency to first occurrence to the platform quadrant during the probe trial did not reveal a significant difference between the groups. (D) Time spent in the platform quadrant did not differ significantly between groups. (E) The frequency of platform crossings indicating when the mouse swam over the area where the hidden platform was placed in the MWM was significantly increased in animals treated with a combination of ACP-105/ERB-186 (p < 0.05). (F) Probe trial analysis revealed a significant increase in the time spent in the hidden platform zone in mice treated with a combination of ACP and ERβ agonist (p < 0.05). (G) A test of working memory, reversal learning, was conducted one day after the probe trial. Mice had to relearn a new location of the hidden platform. There was no significant difference between the groups. (H) Swim speed did not differ between the groups. Data expressed as means ± SEM. Asterisk denotes statistical significance (*p < 0.05; ***p < 0.0001).