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Reagents and conditions: (a) Dess–Martin periodinane, CH2Cl2, 25 °C; (b) Ph2P(O)CH2SO2NHBoc, LiHMDS, THF–DMF, −78 → 25 °C, 45% over 2 steps; (c) Pd/C, H2, MeOH; (f) TFA, CH2Cl2, 0 °C, 87% over 2 steps; (e) biotin–NHS, Cs2CO3, DMF, 0 → 25 °C; (f) 50% aqueous TFA, 0 °C, 60% over 2 steps.
