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. 2013 Dec 13;63(1):323–331. doi: 10.2337/db13-1153

Figure 2.

Figure 2

Susceptibility and resistance HLA epitopes have an additive effect. A: The number of susceptibility epitopes was calculated for each type 1 diabetic patient and control subject. The maximum number for any individual was 12 (two alleles each for HLA-B, -C, -DRB1, -DQA1, -DQB1, and -DPB1). The data were correlated with the age of disease onset. For each age range, the average number of epitopes and 95% CI are shown. No ages were available for the control subjects. B: The number of resistance epitopes was calculated and correlated with the age of disease onset as in A. The maximum number for each individual was six (two alleles each for HLA-DRB1, -DQA1, and -DQB1). A one-way ANOVA revealed significant differences between the groups [F(5.2, 1,792) = 192.9 (P < 0.0001) and F(5,1972) = 159.2 (P < 0.0001) for A and B, respectively].