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. 2014 Jan;95(1):9–18. doi: 10.1189/jlb.1112587

Figure 2. Functional analysis and gene network of Mmp28-dependent genes.

Figure 2.

(A) A functional analysis of Mmp28-dependent genes in LPS-treated (M1) macrophages. Processes are color-coded, based on their enrichment significance. Deletion of Mmp28 enhances the inflammatory, stress, and apoptotic responses of M1. (B) Increased inflammatory gene network in LPS-stimulated Mmp28−/− macrophages compared with WT cells (n=3/genotype/condition). Several densely connected, proinflammatory network nodes that differ between LPS-stimulated Mmp28−/− and WT BMDMs have been labeled (red=increased expression in Mmp28−/− cells; green=decreased expression in Mmp28−/− cells). Genes are organized by known localization of the protein: black background (secreted); yellow (membrane); light gray (cytoplasmic); dark gray (nuclear). INHBA, Inhibin-βA; IER3, immediate early response 3; MAP3K4, mitogen-activated protein kinase kinase kinase 4, MEK4, mitogen-activated protein kinase kinase 4; IFN-β1; OSM, oncostatin M.