FIG. 7.

Early, but not dHT increased the proportion of TREM2-positive macrophages. Representative micrographs of double-labeled TREM2 and CD68-positive phagocytes. A brain from the eHT group at day 7 shows that TREM2 is expressed in CD68-positive cells at the infarct border (red; TREM2, green; CD68, blue; DAPI) (A). The proportion of the TREM2-positive CD68-positive phagocytes was significantly increased in the eHT group (B). High-power views of the staining is shown in (C–F). TREM2 (D) is highly colocalized with CD68-positive cells (C). DAPI (E). Merged image (F) (^★p<0.01). Scale bar=80 μm. Color images available online at www.liebertpub.com/ther