Table 1.
Cox regression analysis for OS (multivariate analysis)—analysis performed on 932 patients (304 events) with all data available
| Characteristics | HR (95% CI) | P-value |
|---|---|---|
| Age (years) | ||
| ≤1 | 2.07 (1.04–4.12) | 0.0005 |
| 2–3 | 0.86 (0.58–1.26) | |
| 4–10 | 0.65 (0.50–0.86) | |
| >10 | 1 | |
| Signs of MI | ||
| None | 1 | <0.0001 |
| CNP and/or CBBE | 1.77 (1.28–2.45) | |
| ICE±CNP±CBBE | 2.14 (1.58–2.91) | |
| Size of tumor (cm) | ||
| ≤5 | 1 | 0.004 |
| >5 | 1.42 (1.11–1.80) | |
| Histology | ||
| Embryonal RMS | 1 | 0.030 |
| Alveolar RMS | 1.40 (1.06–1.83) | |
| RMS NOS | 1.44 (0.91–2.28) | |
| Site (if RT delivered) | ||
| Favorable | 1 | 0.005 |
| Unfavorable | 1.44 (1.12–1.85) | |
| Site (if no RT delivered) | ||
| Favorable | 1 | 0.286 |
| Unfavorable | 0.68 (0.33–1.38) | |
| RT given (favorable site) | ||
| No | 1 | <0.0001 |
| Yes | 0.35 (0.23–0.54) | |
| RT given (unfavorable site) | ||
| No | 1 | 0.362 |
| Yes | 0.74 (0.39–1.40) | |
CI, confidence interval; CNP, cranial nerve palsy; CBBE, cranial base bone erosion; ICE, intracranial extension; RMS, rhabdomyosarcoma; NOS, not otherwise specified; RT, radiation therapy.