Illustration of PIRPLE convergence properties on the CBCT phantom data example. A) Objective function value as a function of iteration. Each full iteration is comprised of an image update followed by a registration update. The differences between the objective function value at each iteration, Φ[n], and its value at the solution, Φ∞. Values are shown immediately after an image update at n=0.5, 1.5, 2.5, etc. and immediately after a registration updates at n=1,2,3, etc. B) Global RMSE (relative to a fully sampled PLE reconstruction) as a function of iteration (image updates only).