FIG. 8.

Visualization of myelopoiesis in sections of femurs derived from mice treated under various protocols (1,000× magnification, H&E staining). (A) Control mouse treated with 0.9% NaCl. In the bone marrow, colonies of all cell lineages are seen with a not significant prevalence of the erythropoietic lineage. Within leukopoiesis, the most dominant is myelopoiesis. (B) Control mouse treated with transferrin. The picture does not differ from the previous one. (C) Mouse treated with rmLF after 24 h shows activation of the bone marrow. An increase of the myelocyte number and band forms in bone marrow sinusoids as compared to control mice. (D) Mouse treated with rmLF after 48 h. Even more intense myelopoiesis; the strongest for metamyelocytes, bands, and neutrophils. myelocyte, red arrow; band, orange arrow; neutrophil, green arrow; H&E, hematoxylin and eosin. Color images available online at www.liebertpub.com/scd